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Providers / Bioss Secondary Antibodies / Rat secretory IgA Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated

Description:

Size: 0.2ml

Catalog no.: bs-0645R-A647

Price: 121 EUR

Get for 121 EUR on Gentaur.com

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Product details

Cross reactivity

Rat

Additional isotype

IgA

Modification site

None

Host Organism

Rabbit

Concentration

1ug/ul

Tested applications

IF(IHC-P)

French translation

anticorps

Modification

Unmodified

Additional conjugation

Alexa Fluor

Conjugation

ALEXA FLUOR® 647

Target antigen

Rat secretory IgA

Latin name

Rattus norvegicus

Clone

Polyclonal antibody

Clonality

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:500-2000)

Group

Polyclonals and antibodies

Category

Conjugated Secondary Antibody

Purification method

This antibody has been purified via Protein A.

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to one year.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Properties

For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Secondary Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Immunoglobulin A (IgA, also referred to as sIgA) is an antibody that plays a critical role in immune function in the mucous membranes. More IgA is produced in mucosal linings than all other types of antibody combined. Examples are EMA, ACA ELISA test kits and for diagnostic detection the IgA of Anti-Beta-2 Glycoprotein 1; β2-Glycoprotein 1 Antibodies; Beta 2GP1 Ab, Beta-2 Glycoprotein 1 Antibodies IgG, IgM, and IgAs.

Background of the target antigen

IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.