Modification Site
None
Group I mGLUR Antibody, ALEXA FLUOR 594
Description:
Size: 100ul
Catalog no.: bs-1803R-A594
Price: 380 EUR
Product details
French translation
anticorps
Subcellular location
Cytoplasm
Clonality
Polyclonal
Gene ID Number
2911, 2915
Modification
Unmodified
Concentration
1ug per 1ul
Excitation emission
590nm/617nm
Immunogen range
681-706/1194
Target Antigen
Group I mGLUR
Tested applications
FCM, IF(IHC-P)
Conjugated with
ALEXA FLUOR® 594
Conjugated
Alexa conjugate 1
Crossreactivity
Human, Mouse, Rat
Clone
Polyclonal antibody
Purification
Purified by Protein A.
Category
Conjugated Primary Antibodies
Conjugation
Alexa Fluor,ALEXA FLUOR® 594
Host Organism
Rabbit (Oryctolagus cuniculus)
Recommended dilutions
FCM(1:20-100), IF(IHC-P)(1:50-200)
Also known as
Anti-Group I mGLUR PAb ALEXA FLUOR 594
Specificity
This is a highly specific antibody against Group I mGLUR.
Long name
Group I mGLUR Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GRM1
Synonyms
glutamate receptor metabotropic 1; Glutamate Receptor Metabotropic 1;Metabotropic glutamate receptor 1; mGluR1;MGLUR1; GRM1_HUMAN; MGLUR5; mGlur5; GRM5; GRM5_HUMAN.
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Properties
For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Background of the antigen
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].