Gene ID Number
2260
FGFR1 (Tyr307) Antibody, ALEXA FLUOR 647
Description:
Size: 100ul
Catalog no.: bs-5325R-A647
Price: 350 EUR
Product details
Modification Site
Tyr307
French translation
anticorps
Tested applications
IF(IHC-P)
Clonality
Polyclonal
Concentration
1ug per 1ul
Excitation emission
650nm/665nm
Target Antigen
FGFR1 Tyr307
Subcellular location
Extracellular
Modification
Phosphorylation
Conjugated with
ALEXA FLUOR® 647
Crossreactivity
Human, Mouse, Rat
Recommended dilutions
IF(IHC-P)(1:50-200)
Clone
Polyclonal antibody
Purification
Purified by Protein A.
Conjugation
Alexa Fluor,ALEXA FLUOR 647
Category
Conjugated Primary Antibodies
Host Organism
Rabbit (Oryctolagus cuniculus)
Also known as
Anti-FGFR1 Tyr307 PAb ALEXA FLUOR 647
Specificity
This is a highly specific antibody against FGFR1 Tyr307.
Long name
FGFR1 (Tyr307) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr307
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms
FGFR1 phospho Y307; p-FGFR1 phospho Y307; bFGF R; BFGFR; C FGR; CD 331; CD331; CD331 antigen; CEK; FGFBR; FGFR 1; Fibroblast growth factor receptor 1; FLG; FLG protein; FLJ14326; FLT 2; FLT2; Fms like tyrosine kinase 2; Fms related tyrosine kinase 2; Fms related tyrosine kinase 2 Pfefer syndrome; H2; H3; H4; H5; HBGFR; Heparin binding growth factor receptor; Hydroxyaryl protein kinase; KAL 2; KAL2; MFR; N SAM; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Basic fibroblast growth factor receptor 1.
Properties
For facs or microscopy Alexa 1 conjugate.Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-FGFR1 Tyr307 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Background of the antigen
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.