Target Antigen
HES2
HES2
None
54626
IF(IHC-P)
anticorps
Polyclonal
Unmodified
1ug per 1ul
343nm/442nm
ALEXA FLUOR® 350
Human, Mouse, Rat
Polyclonal antibody
IF(IHC-P)(1:50-200)
Purified by Protein A.
Alexa Fluor,ALEXA FLUOR 350
Conjugated Primary Antibodies
Anti-HES2 PAb ALEXA FLUOR 350
Rabbit (Oryctolagus cuniculus)
This is a highly specific antibody against HES2.
HES2 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HES2
bHLHb40; Class B basic helix loop helix protein 40; Hairy and enhancer of split 2 Drosophila; Transcription factor HES 2; HES2_HUMAN.
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.