Target Antigen
NIMP
NIMP Antibody, ALEXA FLUOR 594
Description:
Size: 100ul
Catalog no.: bs-8334R-A594
Price: 380 EUR
Product details
Modification Site
None
Gene ID Number
84816
Tested applications
IF(IHC-P)
French translation
anticorps
Modification
Unmodified
Clonality
Polyclonal
Excitation emission
590nm/617nm
Concentration
1ug per 1ul
Crossreactivity
Human, Mouse, Rat
Conjugated with
ALEXA FLUOR® 594
Conjugated
Alexa conjugate 1
Recommended dilutions
IF(IHC-P)(1:50-200)
Clone
Polyclonal antibody
Purification
Purified by Protein A.
Category
Conjugated Primary Antibodies
Also known as
Anti-NIMP PAb ALEXA FLUOR 594
Conjugation
Alexa Fluor,ALEXA FLUOR® 594
Host Organism
Rabbit (Oryctolagus cuniculus)
Specificity
This is a highly specific antibody against NIMP.
Long name
NIMP Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NIMP/RTN4IP1
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Properties
For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Synonyms
mitochondrial; NIMP; NOGO interacting mitochondrial protein; NOGO-interacting mitochondrial protein; Reticulon 4 interacting protein 1; Reticulon 4 interacting protein 1, mitochondrial; Reticulon-4-interacting protein 1; RT4I1_HUMAN; Rtn4ip1; NIMP/RTN4IP1.
Background of the antigen
Appears to be a potent inhibitor of regeneration following spinal cord injury.Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NIMP (NOGO-interacting mitochondrial protein), also known as RTN4IP1 (Reticulon-4-interacting protein 1), is a 396 amino acid mitochondrial protein that contains a C-terminal oxidoreductaselike domain and numerous sites for phosphorylation. NIMP is expressed in mitochondrial-rich tissue such as kidney, heart, skeletal muscle and specific regions within the nervous system. Through interaction with Nogo, it is likely that NIMP plays a role in Nogo-induced inhibition of neurite growth. There are three isoforms of NIMP that are produced as a result of alternative splicing events.