Description:

Size: 100ul

Catalog no.: bs-13544R-A594

Price: 380 EUR

Product details

Gene ID Number

2982

Modification Site

None

Swiss Prot

Q02108

Subcellular location

Cytoplasm

Tested applications

IF(IHC-P)

French translation

anticorps

Modification

Unmodified

Clonality

Polyclonal

Excitation emission

590nm/617nm

Concentration

1ug per 1ul

Immunogen range

330-380/690

Crossreactivity

Human, Mouse, Rat

Conjugated with

ALEXA FLUOR® 594

Conjugated

Alexa conjugate 1

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

Purification

Purified by Protein A.

Target Antigen

Guanylyl Cyclase alpha 1

Category

Conjugated Primary Antibodies

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-Guanylyl Cyclase alpha 1 PAb ALEXA FLUOR 594

Long name

Guanylyl Cyclase alpha 1 Antibody, ALEXA FLUOR 594 Conjugated

Specificity

This is a highly specific antibody against Guanylyl Cyclase alpha 1.

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Description

The Anti-Guanylyl Cyclase alpha 1 is a α- or alpha protein sometimes glycoprotein present in blood.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Guanylyl Cyclase alpha 1

Synonyms

GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A1; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit; GUCY1A3

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.