Description:

Size: 100ul

Catalog no.: bs-12156R-A555

Price: 380 EUR

Product details

Modification Site

None

French translation

anticorps

Tested applications

IF(IHC-P)

Clonality

Polyclonal

Modification

Unmodified

Concentration

1ug per 1ul

Excitation emission

553nm/568nm

Target Antigen

HDAC4 + 5 + 9

Conjugated with

ALEXA FLUOR® 555

Crossreactivity

Human, Mouse, Rat

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-HDAC4 + 5 + 9 PAb ALEXA FLUOR 555

Specificity

This is a highly specific antibody against HDAC4 + 5 + 9.

Long name

HDAC4 + 5 + 9 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC4 + 5 + 9

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms

AHO3 ;Antigen NY-CO-9 ;BDMR ;HA6116 ;HD4 ;HD5 ;HD7 ;HD7b ;HD9 ;HDAC ;HDAC-4 ;HDACA ;HDAC4 ;HDAC5 ;HDAC7 ;HDAC7B ;HDAC9 ;HDAC9B ;HDAC9FL ;HDACA ;HDRP ;Histone deacetylase 4 ;Histone deacetylase 5 ;Histone deacetylase 7B ;Histone deacetylase 9 ;Histone deacetylase-related protein ;MEF2-interacting transcription repressor MITR ;MITR ;NY-CO-9; HDAC4_HUMAN; HDAC5_HUMAN; HDAC9_HUMAN.

Background of the antigen

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-7, have been identified as histone deacetylases. Mammalian HDAC7 interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.