Description:

Size: 100ul

Catalog no.: bs-0252R-A488

Price: 380 EUR

Product details

Gene ID Number

2908

Modification Site

None

Swiss Prot

P04150

French translation

anticorps

Clonality

Polyclonal

Modification

Unmodified

Excitation emission

499nm/519nm

Concentration

1ug per 1ul

Immunogen range

230-280/777

Conjugation

Alexa Fluor

Tested applications

FCM, IF(IHC-P)

Conjugated with

ALEXA FLUOR® 488

Crossreactivity

Human, Mouse, Rat

Subcellular location

Cytoplasm, Nucleus

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Target Antigen

Glucocorticoid receptor

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Recommended dilutions

FCM(1:20-100), IF(IHC-P)(1:50-200)

Also known as

Anti-Glucocorticoid receptor PAb ALEXA FLUOR 488

Long name

Glucocorticoid receptor Antibody, ALEXA FLUOR 488 Conjugated

Specificity

This is a highly specific antibody against Glucocorticoid receptor .

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Synonyms

GR; GCR; GRL; GCCR; GCRST; Glucocorticoid receptor; Nuclear receptor subfamily 3 group C member 1; NR3C1

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Glucocorticoid receptor

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Glucocorticoid receptor has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.