Description:

Size: 100ul

Catalog no.: bs-3748R-A555

Price: 350 EUR

Product details

French translation

anticorps

Tested applications

IF(IHC-P)

Clonality

Polyclonal

Modification

Acetylation

Excitation emission

553nm/568nm

Concentration

1ug per 1ul

Modification Site

Ac-K10/p-Ser11

Conjugated with

ALEXA FLUOR® 555

Crossreactivity

Human, Mouse, Rat

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Target Antigen

Acetyl and Histone H3(Ac-K10/p-Ser11)

Also known as

Anti-Acetyl and Histone H3(Ac-K10/p-Ser11) PAb ALEXA FLUOR 555

Long name

Acetyl and Histone H3(Ac-K10/p-Ser11) Antibody, ALEXA FLUOR 555 Conjugated

Synonyms

H3 histone family member E pseudogene; H3F3; HIST3H3; Histone H3 3 pseudogene.

Specificity

This is a highly specific antibody against Acetyl and Histone H3(Ac-K10/p-Ser11).

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Description

N terminal acetylation or CH3CO as epigenetic regulation of Anti-Acetyl and Histone H3(Ac-K10/p-Ser11) by NATs.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Acetyl and Histone H3 (Ac-Lys10/p-Ser11)

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.