Description:

Size: 100ul

Catalog no.: bs-12052R-A555

Price: 380 EUR

Product details

Modification Site

None

Crossreactivity

Human

French translation

anticorps

Subcellular location

Cytoplasm

Tested applications

IF(IHC-P)

Modification

Unmodified

Clonality

Polyclonal

Concentration

1ug per 1ul

Excitation emission

553nm/568nm

Conjugated with

ALEXA FLUOR® 555

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

Target Antigen

5HT3D + 5HT3E Receptor

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-5HT3D + 5HT3E Receptor PAb ALEXA FLUOR 555

Long name

5HT3D + 5HT3E Receptor Antibody, ALEXA FLUOR 555 Conjugated

Specificity

This is a highly specific antibody against 5HT3D + 5HT3E Receptor.

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human 5HT3D + 5HT3E Receptor

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms

5 HT3 D; 5 HT3 E; 5 HT3c1; 5 HT3D; 5 HT3E; 5 hydroxytryptamine serotonin receptor 3 family member D; 5 hydroxytryptamine serotonin receptor 3 family member E; 5 hydroxytryptamine receptor 3 subunit D; 5 hydroxytryptamine receptor 3 subunit E; 5 hydroxytryptamine receptor 3D; 5 hydroxytryptamine receptor 3E; 5HT3D; HTR3D; HTR3E; MGC119636; MGC119637; MGC120035; MGC120036; MGC120037; Serotonin 5 HT 3D receptor; Serotonin receptor 3D; Serotonin receptor 3E; 5HT3D_HUMAN; 5HT3E_HUMAN.

Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Background of the antigen

Serotonin is a monoamine neurotransmitter that is made in serotonergic neurons in the CNS (central nervous system) and is important in the regulation of mood, sleep, vomiting, sexuality and appetite. 5-HT3 (5-hydroxytryptamine-3) receptor is the only ligand-gated ion channel within the family of serotonin receptors. It is composed of five subunits consisting of SR-3A, SR-3B, HTR3C, HTR3D and HTR3E. HTR3D (5-hydroxytryptamine receptor 3D), also known as Serotonin receptor 3D, is a 454 amino acid multi-pass membrane protein that is one components of the pentaheteromeric complex that forms the 5-HT3 receptor. HTR3D must be co-expressed with SR-3A to form a functional 5-HT3 receptor complex on the plasma membrane. Until it is complexed with SR-3A, HTR3D is localized within the endoplasmic reticulum. Expression of HTR3D is restricted to kidney, colon and liver. There are three different isoforms of HTR3D that are expressed as a result of alternative splicing events.