Description:

Size: 100ul

Catalog no.: bs-7548R-A488

Price: 380 EUR

Product details

Gene ID Number

2243

Modification Site

None

Swiss Prot

P02671

Subcellular location

Secreted

Tested applications

IF(IHC-P)

French translation

anticorps

Immunogen range

70-105/866

Clonality

Polyclonal

Modification

Unmodified

Conjugation

Alexa Fluor

Excitation emission

499nm/519nm

Concentration

1ug per 1ul

Conjugated with

ALEXA FLUOR® 488

Crossreactivity

Human, Mouse, Rat

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Target Antigen

Fibrinogen alpha chain

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Synonyms

Fib2; Fibrinogen alpha chain; FGA

Also known as

Anti-Fibrinogen alpha chain PAb ALEXA FLUOR 488

Long name

Fibrinogen alpha chain Antibody, ALEXA FLUOR 488 Conjugated

Specificity

This is a highly specific antibody against Fibrinogen alpha chain.

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Description

The Anti-Fibrinogen alpha chain is a α- or alpha protein sometimes glycoprotein present in blood.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fibrinogen alpha chain

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Fibrinogen alpha chain has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.