Description:

Size: 100ul

Catalog no.: bs-8440R-A594

Price: 350 EUR

Product details

Gene ID Number

25

Tested applications

IF(IHC-P)

French translation

anticorps

Modification Site

Tyr393+439

Clonality

Polyclonal

Excitation emission

590nm/617nm

Concentration

1ug per 1ul

Modification

Phosphorylation

Target Antigen

ABL1+2Tyr393+439

Crossreactivity

Human, Mouse, Rat

Conjugated

Alexa conjugate 1

Conjugated with

ALEXA FLUOR® 594

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-ABL1+2Tyr393+439 PAb ALEXA FLUOR 594

Specificity

This is a highly specific antibody against ABL1+2Tyr393+439.

Long name

ABL1+2(Tyr393+439) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human c-Abl around the phosphorylation site of Tyr393

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms

c Abl (phospho Y412) (isoform b); phospho-c-ABL1 (Try412) (isoform b); c-Abl 1/2(phospho Y393/429); c-ABL1/2(phospho Tyr393/429); p-c-ABL1/2(Tyr393/429); tyrosine-protein kinase ABL1 isoform b; Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150 ; Proto oncogene tyrosine protein kinase ABL1; Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN.

Background of the antigen

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].