Description:

Size: 100ul

Catalog no.: bs-12063R-A555

Price: 380 EUR

Product details

Modification Site

None

French translation

anticorps

Modification

Unmodified

Clonality

Polyclonal

Excitation emission

553nm/568nm

Concentration

1ug per 1ul

Subcellular location

Extracellular

Tested applications

FCM, IF(IHC-P)

Conjugated with

ALEXA FLUOR® 555

Crossreactivity

Human, Mouse, Rat

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Target Antigen

GABRA6/GABA A Receptor alpha 6

Recommended dilutions

FCM(1:20-100), IF(IHC-P)(1:50-200)

Also known as

Anti-GABRA6/GABA A Receptor alpha 6 PAb ALEXA FLUOR 555

Long name

GABRA6/GABA A Receptor alpha 6 Antibody, ALEXA FLUOR 555 Conjugated

Specificity

This is a highly specific antibody against GABRA6/GABA A Receptor alpha 6.

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GABRA6/GABA A Receptor alpha 6

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms

GABA A; GABA A Receptor alpha 6 polypeptide; GABA A receptor alpha 6; GABA A receptor subunit alpha 6; GABA subunit A receptor alpha 6; GABAA receptor subunit alpha-6; GABRA 6; GABRA6; Gamma aminobutyric acid A receptor alpha 6; Gamma aminobutyric acid GABA A receptor alpha 6; Gamma aminobutyric acid receptor subunit alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; GBRA6_HUMAN; MGC116903; MGC116904.

Description

The Anti-GABRA6/GABA A Receptor alpha 6 is a α- or alpha protein sometimes glycoprotein present in blood.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Background of the antigen

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R gamma 1-3, GABAA R gamma , GABAA R delta. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.