Description:

Size: 100ul

Catalog no.: bs-3208R-A350

Price: 350 EUR

Product details

Gene ID Number

3718

Swiss Prot

P52333

French translation

anticorps

Tested applications

IF(IHC-P)

Clonality

Polyclonal

Concentration

1ug per 1ul

Excitation emission

343nm/442nm

Immunogen range

971-990/1124

Modification

Phosphorylation

Modification Site

Tyr980 + Tyr981

Conjugated with

ALEXA FLUOR® 350

Crossreactivity

Human, Mouse, Rat

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

Target Antigen

Jak3 Tyr980 + Tyr981

Purification

Purified by Protein A.

Subcellular location

Cytoplasm, Cell membrane

Conjugation

Alexa Fluor,ALEXA FLUOR 350

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-Jak3 Tyr980 + Tyr981 PAb ALEXA FLUOR 350

Long name

Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 350 Conjugated

Specificity

This is a highly specific antibody against Jak3 Tyr980 + Tyr981.

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981

Synonyms

JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; Tyrosine-protein kinase JAK3; Janus kinase 3; Leukocyte janus kinase; JAK3

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.