Description:

    Size: 100ul

    Catalog no.: bs-13360R-A594

    Price: 380 EUR

    Product details

    Gene ID Number

    9815

    Target Antigen

    GIT2

    Modification Site

    None

    Tested applications

    IF(IHC-P)

    French translation

    anticorps

    Modification

    Unmodified

    Clonality

    Polyclonal

    Excitation emission

    590nm/617nm

    Concentration

    1ug per 1ul

    Crossreactivity

    Human, Mouse, Rat

    Conjugated with

    ALEXA FLUOR® 594

    Conjugated

    Alexa conjugate 1

    Recommended dilutions

    IF(IHC-P)(1:50-200)

    Clone

    Polyclonal antibody

    Purification

    Purified by Protein A.

    Category

    Conjugated Primary Antibodies

    Also known as

    Anti-GIT2 PAb ALEXA FLUOR 594

    Conjugation

    Alexa Fluor,ALEXA FLUOR® 594

    Host Organism

    Rabbit (Oryctolagus cuniculus)

    Specificity

    This is a highly specific antibody against GIT2.

    Long name

    GIT2 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated

    Cross-reactive species details

    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

    Source

    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GIT2

    Storage conditions

    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

    Properties

    For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

    Synonyms

    ARF GAP GIT2; ARF GTPase activating protein GIT2; ARF GTPase-activating protein GIT2; CAT 2; CAT-2; CAT2; Cool associated tyrosine phosphorylated protein 2; Cool interacting tyrosine phosphorylated protein 2; Cool-interacting tyrosine-phosphorylated protein 2; DKFZp686G01261; G protein coupled receptor kinase interacting ArfGAP 2; G protein coupled receptor kinase interactor 2; G protein-coupled receptor kinase-interactor 2; GIT 2; GIT2; GIT2_HUMAN; GRK interacting protein 2; GRK-interacting protein 2; KIAA0148; MGC760; ARF GTPase-activating protein GIT2; Cool-interacting tyrosine-phosphorylated protein 2; G protein-coupled receptor kinase-interactor 2.

    Background of the antigen

    Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).