Description:

Size: 100ul

Catalog no.: bs-0024M-A488

Price: 380 EUR

Product details

Modification Site

None

Gene ID Number

29192

Swiss Prot

P97887

Immunogen range

1-50/467

French translation

anticorps

Subcellular location

Cytoplasm

Tested applications

IF(IHC-P)

Modification

Unmodified

Clonality

Polyclonal

Excitation emission

499nm/519nm

Concentration

1ug per 1ul

Conjugation

Alexa Fluor

Target Antigen

presenilin 1

Conjugated with

ALEXA FLUOR® 488

Crossreactivity

Human, Rat, Rabbit

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Host Organism

Mouse (Mus musculus)

Purification

Purified by Protein A.

Category

Conjugated Primary Antibodies

Also known as

Anti-presenilin 1 PAb ALEXA FLUOR 488

Synonyms

Presenilin-1; PS-1; Protein S182; Psen1; Psnl1

Specificity

This is a highly specific antibody against presenilin 1.

Long name

presenilin 1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated

Source

KLH conjugated synthetic peptide derived from rat presenilin 1

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-presenilin 1 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).