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Providers / Bioss Primary Conjugated Antibodies. ALEXA FLUOR / LRP6 (Ser1490) Antibody, ALEXA FLUOR 488

Description:

Size: 100ul

Catalog no.: bs-3253R-A488

Price: 350 EUR

Get for 350 EUR on Gentaur.com

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Product details

Gene ID Number

4040

Swiss Prot

O75581

Modification Site

Ser1490

French translation

anticorps

Subcellular location

Cytoplasm

Clonality

Polyclonal

Conjugation

Alexa Fluor

Concentration

1ug per 1ul

Excitation emission

499nm/519nm

Target Antigen

LRP6 Ser1490

Crossreactivity

Human, Mouse

Immunogen range

1470-1520/1613

Modification

Phosphorylation

Conjugated with

ALEXA FLUOR® 488

Tested applications

IF(IHC-P), IF(ICC)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-LRP6 Ser1490 PAb ALEXA FLUOR 488

Recommended dilutions

IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

Specificity

This is a highly specific antibody against LRP6 Ser1490.

Long name

LRP6 (Ser1490) Polyclonal Antibody, ALEXA FLUOR 488 Conjugated

Synonyms

ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-LRP6 Ser1490 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).