0208080893 [email protected]
Providers / Bioss Primary Conjugated Antibodies. ALEXA FLUOR / Merlin (Ser518) Antibody, ALEXA FLUOR 488

Description:

Size: 100ul

Catalog no.: bs-3291R-A488

Price: 350 EUR

Get for 350 EUR on Gentaur.com

/ningbo-assets-bio/graphics/prods/bigs/bigs0.jpg

Product details

Gene ID Number

4771

Modification Site

Ser518

Swiss Prot

P35240

Tested applications

IF(IHC-P)

French translation

anticorps

Clonality

Polyclonal

Conjugation

Alexa Fluor

Immunogen range

500-545/590

Concentration

1ug per 1ul

Excitation emission

499nm/519nm

Target Antigen

Merlin (Ser518)

Modification

Phosphorylation

Crossreactivity

Human, Mouse, Rat

Conjugated with

ALEXA FLUOR® 488

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

Purification

Purified by Protein A.

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Subcellular location

Cytoplasm, Nucleus, Cell membrane

Also known as

Anti-Merlin (Ser518) PAb ALEXA FLUOR 488

Long name

Merlin (Ser518) Antibody, ALEXA FLUOR 488 Conjugated

Specificity

This is a highly specific antibody against Merlin (Ser518).

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518

Synonyms

ACN; SCH; BANF; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; NF2

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Merlin (Ser518) has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.