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Providers / Bioss Primary Conjugated Antibodies. ALEXA FLUOR / Wee1(Ser123) Antibody, ALEXA FLUOR 555

Description:

Size: 100ul

Catalog no.: bs-5218R-A555

Price: 350 EUR

Get for 350 EUR on Gentaur.com

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Product details

Gene ID Number

7465

Modification Site

Ser123

Swiss Prot

P30291

Subcellular location

Nucleus

French translation

anticorps

Tested applications

IF(IHC-P)

Clonality

Polyclonal

Target Antigen

Wee1 Ser123

Excitation emission

553nm/568nm

Immunogen range

100-150/646

Concentration

1ug per 1ul

Modification

Phosphorylation

Crossreactivity

Human, Mouse, Rat

Conjugated with

ALEXA FLUOR® 555

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-Wee1 Ser123 PAb ALEXA FLUOR 555

Specificity

This is a highly specific antibody against Wee1 Ser123.

Synonyms

WEE1A; WEE1hu; Wee1-like protein kinase; Wee1A kinase; WEE1

Long name

Wee1(Ser123) Polyclonal Antibody, ALEXA FLUOR 555 Conjugated

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human Wee1 around the phosphorylation site of Ser123 [SS(p-S)PV]

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.