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Providers / Bioss Primary Conjugated Antibodies. ALEXA FLUOR / LRP6 (Ser1490) Antibody, ALEXA FLUOR 647

Description:

Size: 100ul

Catalog no.: bs-3253R-A647

Price: 350 EUR

Get for 350 EUR on Gentaur.com

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Product details

Gene ID Number

4040

Swiss Prot

O75581

Modification Site

Ser1490

French translation

anticorps

Subcellular location

Cytoplasm

Clonality

Polyclonal

Concentration

1ug per 1ul

Excitation emission

650nm/665nm

Target Antigen

LRP6 Ser1490

Crossreactivity

Human, Mouse

Immunogen range

1470-1520/1613

Modification

Phosphorylation

Conjugated with

ALEXA FLUOR® 647

Tested applications

IF(IHC-P), IF(ICC)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 647

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-LRP6 Ser1490 PAb ALEXA FLUOR 647

Recommended dilutions

IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

Specificity

This is a highly specific antibody against LRP6 Ser1490.

Long name

LRP6 (Ser1490) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated

Synonyms

ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Background of the antigen

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-LRP6 Ser1490 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.