Description:

    Size: 100ul

    Catalog no.: bs-3412R-A594

    Price: 350 EUR

    Product details

    Gene ID Number

    6464

    Modification Site

    Tyr427

    Swiss Prot

    P29353

    Tested applications

    IF(IHC-P)

    French translation

    anticorps

    Target Antigen

    SHC Tyr427

    Clonality

    Polyclonal

    Excitation emission

    590nm/617nm

    Concentration

    1ug per 1ul

    Immunogen range

    405-455/583

    Modification

    Phosphorylation

    Crossreactivity

    Human, Mouse, Rat

    Conjugated with

    ALEXA FLUOR® 594

    Conjugated

    Alexa conjugate 1

    Clone

    Polyclonal antibody

    Recommended dilutions

    IF(IHC-P)(1:50-200)

    Purification

    Purified by Protein A.

    Subcellular location

    Cytoplasm, Mitochondrion

    Conjugation

    Alexa Fluor,ALEXA FLUOR® 594

    Category

    Conjugated Primary Antibodies

    Host Organism

    Rabbit (Oryctolagus cuniculus)

    Also known as

    Anti-SHC Tyr427 PAb ALEXA FLUOR 594

    Specificity

    This is a highly specific antibody against SHC Tyr427.

    Long name

    SHC (Tyr427) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated

    Cross-reactive species details

    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

    Source

    KLH conjugated synthetic phosphopeptide derived from human SHC around the phosphorylation site of Tyr427

    Storage conditions

    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

    Synonyms

    SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1; SHC1

    Properties

    For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

    Background of the antigen

    Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.