Description:

Size: 100ul

Catalog no.: bs-0988R-A594

Price: 380 EUR

Product details

Gene ID Number

7037

Modification Site

None

Swiss Prot

P02786

French translation

anticorps

Modification

Unmodified

Clonality

Polyclonal

Concentration

1ug per 1ul

Immunogen range

620-670/760

Excitation emission

590nm/617nm

Subcellular location

Extracellular

Crossreactivity

Human, Mouse, Rat

Conjugated

Alexa conjugate 1

Conjugated with

ALEXA FLUOR® 594

Clone

Polyclonal antibody

Target Antigen

Transferrin receptor

Purification

Purified by Protein A.

Tested applications

FCM, IF(IHC-P), IF(ICC)

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-Transferrin receptor PAb ALEXA FLUOR 594

Recommended dilutions

FCM(1:20-100), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

Specificity

This is a highly specific antibody against Transferrin receptor.

Long name

Transferrin receptor Polyclonal Antibody, ALEXA FLUOR 594 Conjugated

Synonyms

T9; TR; TFR; p90; CD71; TFR1; TRFR; Transferrin receptor protein 1; TFRC

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Transferrin receptor

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.