Description:

    Size: 100ul

    Catalog no.: bs-5554R-A488

    Price: 350 EUR

    Product details

    Gene ID Number

    5159

    Modification Site

    Tyr579

    Tested applications

    IF(IHC-P)

    French translation

    anticorps

    Clonality

    Polyclonal

    Concentration

    1ug per 1ul

    Excitation emission

    499nm/519nm

    Conjugation

    Alexa Fluor

    Modification

    Phosphorylation

    Conjugated with

    ALEXA FLUOR® 488

    Crossreactivity

    Human, Mouse, Rat

    Recommended dilutions

    IF(IHC-P)(1:50-200)

    Clone

    Polyclonal antibody

    Purification

    Purified by Protein A.

    Target Antigen

    PDGF Receptor beta Tyr579

    Category

    Conjugated Primary Antibodies

    Host Organism

    Rabbit (Oryctolagus cuniculus)

    Also known as

    Anti-PDGF Receptor beta Tyr579 PAb ALEXA FLUOR 488

    Long name

    PDGF Receptor beta (Tyr579) Antibody, ALEXA FLUOR 488 Conjugated

    Specificity

    This is a highly specific antibody against PDGF Receptor beta Tyr579.

    Cross-reactive species details

    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

    Source

    KLH conjugated synthetic phosphopeptide derived from human PDGFRB around the phosphorylation site of Tyr579 [HE(p-Y)IY]

    Storage conditions

    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

    Synonyms

    PDGFRBphospho Y579; PDGF Receptor beta phospho Y579; PDGF Receptor beta phospho Tyr579; Beta platelet derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD 140B; CD140 antigen-like family member B; CD140B; CD140B; CD140b antigen; JTK12; OTTHUMP00000160528; PDGF R beta; PDGF-R-beta; PDGFR 1; PDGFR; PDGFR beta; PDGFR1; PDGFRB; PGFRB_HUMAN; Platelet derived growth factor receptor 1; Platelet derived growth factor receptor beta; Platelet derived growth factor receptor beta; polypeptide.

    Properties

    For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-PDGF Receptor beta Tyr579 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

    Description

    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

    Background of the antigen

    This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq].