Description:

Size: 100ul

Catalog no.: bs-0916R-A488

Price: 380 EUR

Product details

Modification Site

None

Gene ID Number

22242

Swiss Prot

Q91X17

Tested applications

IF(IHC-P)

French translation

anticorps

Target Antigen

MCKD2/UMOD

Modification

Unmodified

Clonality

Polyclonal

Conjugation

Alexa Fluor

Immunogen range

120-170/640

Concentration

1ug per 1ul

Excitation emission

499nm/519nm

Crossreactivity

Human, Mouse, Rat

Conjugated with

ALEXA FLUOR® 488

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

Purification

Purified by Protein A.

Subcellular location

Secreted, Cell membrane

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-MCKD2/UMOD PAb ALEXA FLUOR 488

Long name

MCKD2 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated

Specificity

This is a highly specific antibody against MCKD2/UMOD.

Source

KLH conjugated synthetic peptide derived from mouse MCKD2

Synonyms

THP; Urehd1; urehr4; Uromodulin; Tamm-Horsfall urinary glycoprotein; Umod

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-MCKD2/UMOD has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Background of the antigen

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity). Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.