Description:

Size: 100ul

Catalog no.: bs-1812R-A555

Price: 380 EUR

Product details

Gene ID Number

4854

Modification Site

None

Target Antigen

Notch3/4

Tested applications

IF(IHC-P)

French translation

anticorps

Clonality

Polyclonal

Modification

Unmodified

Concentration

1ug per 1ul

Excitation emission

553nm/568nm

Conjugated with

ALEXA FLUOR® 555

Crossreactivity

Human, Mouse, Rat

Clone

Polyclonal antibody

Recommended dilutions

IF(IHC-P)(1:50-200)

Purification

Purified by Protein A.

Conjugation

Alexa Fluor,ALEXA FLUOR 555

Category

Conjugated Primary Antibodies

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-Notch3/4 PAb ALEXA FLUOR 555

Specificity

This is a highly specific antibody against Notch3/4.

Long name

Notch3/4 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated

Source

KLH conjugated synthetic peptide derived from mouse Notch3

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms

hNotch 4;hNotch4;NOTCH 3;NOTCH3;INT 3;INT3;MGC74442;Neurogenic locus notch homolog protein 4;Neurogenic locus notch homolog protein 3;NOTC4_HUMAN;NOTCH-3;NOTCH-4;Notch 4 intracellular domain;Notch homolog 4;NOTCH4 protein;Neurogenic locus notch homolog protein 1; CADASIL; CASIL; Notch homolog 3.

Background of the antigen

NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot).