Description:

Size: 100ul

Catalog no.: bs-5387R-A594

Price: 350 EUR

Product details

Gene ID Number

3065

Subcellular location

Nucleus

Tested applications

IF(IHC-P)

French translation

anticorps

Clonality

Polyclonal

Modification Site

Ser423/424

Excitation emission

590nm/617nm

Concentration

1ug per 1ul

Modification

Phosphorylation

Crossreactivity

Human, Mouse, Rat

Conjugated

Alexa conjugate 1

Conjugated with

ALEXA FLUOR® 594

Target Antigen

HDAC1/2 Ser423/424

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Purification

Purified by Protein A.

Category

Conjugated Primary Antibodies

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Host Organism

Rabbit (Oryctolagus cuniculus)

Also known as

Anti-HDAC1/2 Ser423/424 PAb ALEXA FLUOR 594

Specificity

This is a highly specific antibody against HDAC1/2 Ser423/424.

Long name

HDAC1/2 (Ser423/424) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic phosphopeptide derived from human HDAC1 around phosphorylation site of Ser423

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Properties

For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms

HD 1 Phospho Ser423; HD1; HDAC 1 Phospho Ser423; histone deacetylase 1 Phospho Ser423; Histone deacetylase 1 HD1 Phospho Ser423; Histone deacetylase 1; RPD3 reduced potassium dependency yeast homolog like 1; RPD3 reduced potassium dependency; RPD3; RPD3L1; HDAC2_HUMAN. HDAC2 Phospho Ser424; Histone deacetylase 2 Phospho Ser424.

Background of the antigen

Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.